anon answered on 7 Mar 2017:
I think what most of us here will tell you is that research is mostly based on uncertainities. The only sure thing is that we will get some results, positive or negative is never for sure.
When you set off with something that hasn’t been done before (which is almost everything you’d do in science), you’ll always be uncertain of the outcome. In your mind, you’ll have a certain result you want to get out of the experiment you’re conducting so long as you are working to achieve that, your uncertanities can be controlled to an extent.